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Toplam kayıt 26, listelenen: 1-10
A translational repression complex in developing mammalian neural stem cells that regulates neuronal specification
(Neuron, 2018)
The mechanisms instructing genesis of neuronal sub-types from mammalian neural precursors are not well understood. To address this issue, we have characterized the transcriptional landscape of radial glial precursors (RPs) ...
Target-independent prediction of drug synergies using only drug lipophilicity
(Journal of Chemical Information and Modeling, 2014)
Physicochemical properties of compounds have been instrumental in selecting lead compounds with increased drug-likeness. However, the relationship between physicochemical properties of constituent drugs and the tendency ...
Sex-biased expression of neuroimmune guidance cues in cardiovascular diseases
(15th International Symposium on Health Informatics and Bioinformatics, 2022)
Atherosclerotic vascular disease continues to be a leader of morbidity and mortality. Although sex hormones are known to play a role in this lipid- and inflammatory-driven disease, the underlying mechanisms are largely ...
Modeling gene regulation in liver hepatocellular carcinoma with random forests
(BioMed Research International, 2016)
Liver hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death. Poor understanding of the mechanisms underlying HCC prevents early detection and leads to high mortality. We developed a random forest ...
MEXCOwalk: mutual exclusion and coverage based random walk to identify cancer modules
(Bioinformatics, 2019)
Motivation: Genomic analyses from large cancer cohorts have revealed the mutational heterogeneity problem
which hinders the identification of driver genes based only on mutation profiles. One way to tackle this problem ...
Ranking cancer drivers via betweenness-based outlier detection and random walks
(BMC Bioinformatics, 2021)
Background Recent cancer genomic studies have generated detailed molecular data on a large number of cancer patients. A key remaining problem in cancer genomics is the identification of driver genes. Results
We propose ...
JBASE: Joint Bayesian Analysis of Subphenotypes and Epistasis
(Bioinformatics, 2015)
Motivation: Rapid advances in genotyping and genome-wide association studies have enabled the discovery of many new genotype–phenotype associations at the resolution of individual markers. However, these associations explain ...
MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress
(Autophagy, 2019)
Macroautophagy (autophagy) is an evolutionarily conserved recycling and stress response mechanism. Active at basal levels in eukaryotes, autophagy is upregulated under stress providing cells with building blocks such as ...
Predicting clinical outcomes in neuroblastoma with genomic data integration
(Biology Direct, 2018)
Background: Neuroblastoma is a heterogeneous disease with diverse clinical outcomes. Current risk group models require improvement as patients within the same risk group can still show variable prognosis. Recently collected ...
RBPSponge: genome-wide identification of lncRNAs that sponge RBPs
(Bioinformatics, 2019)
Long non-coding RNAs (lncRNAs) can act as molecular sponge or decoys for an RNA-binding protein (RBP) through their RBP-binding sites, thereby modulating the expression of all target genes of the corresponding RBP of ...