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Toplam kayıt 26, listelenen: 21-26
Community assessment of the predictability of cancer protein and phosphoprotein levels from genomics and transcriptomics
(Cell Systems, 2020)
Cancer is driven by genomic alterations, but the processes causing this disease are largely performed by proteins. However, proteins are harder and more expensive to measure than genes and transcripts. To catalyze developments ...
Sparse data embedding and prediction by tropical matrix factorization
(BMC Bioinformatics, 2021)
Background Matrix factorization methods are linear models, with limited capability to model complex relations. In our work, we use tropical semiring to introduce non-linearity into matrix factorization models. We propose ...
DriveWays: a method for identifying possibly overlapping driver pathways in cancer
(Nature Research, 2020)
The majority of the previous methods for identifying cancer driver modules output nonoverlapping modules. This assumption is biologically inaccurate as genes can participate in multiple molecular pathways. This is particularly ...
PersonaDrive: a method for the identification and prioritization of personalized cancer drivers
(Bioinformatics, 2022)
Motivation:
A major challenge in cancer genomics is to distinguish the driver mutations that are causally linked to cancer from passenger mutations that do not contribute to cancer development. The majority of existing ...
A network-centric framework for the evaluation of mutual exclusivity tests on cancer drivers
(Frontiers in Genetics, 2021)
One of the key concepts employed in cancer driver gene identification is that of mutual exclusivity (ME); a driver mutation is less likely to occur in case of an earlier mutation that has common functionality in the same ...
Inferring RBP-mediated regulation in lung squamous cell carcinoma
(Plos One, 2016)
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of mRNAs. Dysregulations in RBP-mediated mechanisms have been found to be associated with many steps of cancer initiation and progression. Despite ...