Ion channels are water-filled pores formed by membrane proteins abundant in excitable cells' plasma membranes. Ion channels are responsible for converting signals into biological responses. They are primarily engaged in ...

We have studied the cardiac action potential model which consists of 26 nonlinear first-order differential equations in a detailed manner computationally. Later, it has been discussed what is the role of the Ca2+ ion channel ...

Understanding the dynamics of coupled neurons is one of the fundamental problems in the analysis of neuronal model dynamics. The transfer entropy (TE) method is one of the primary analyses to explore the information flow ...

Nöronlar tarafından aksiyon potansiyeli üretimi, enerji gerektiren yoğun bir süreçtir ve nöronların sinyal iletim aktivitesini korumak için ne kadar metabolik enerjinin gerekli olduğunu belirlemek, oldukça pratik öneme ...

Experiments using conventional experimental approaches to capture the dynamics of ion channels are not always feasible, and even when possible and feasible, some can be timeconsuming. In this work, the ionic current–time ...

Mathematical action potential (AP) modeling is a well-established but still-developing area of research to better understand physiological and pathological processes. In particular, changes in AP mechanisms in the isoproterenol ...

The patch-clamp technique is a significant tool in current electrophysiology research, especially in cardiovascular diseases, because it can capture electrical activity of the heart from cardiomyocytes. It is challenging ...

Young-onset hypertension is defined as hypertension diagnosed before the age of40 years. Aortic pulse wave velocity is an indication of aortic stiffness. MRI assessment has beenwell verified compared to invasive pressure ...

Mathematical models for the action potential (AP) generation of the electrically excitable cells including the heart are involved different mechanisms including the voltage-dependent currents with nonlinear time- and ...