The miR125b as biomarkers in the early diagnosis of bladder cancer
Coşkun, Hasan Şenol
Göksu, Sema Sezgin
Aktekin, Mehmet Rıfkı
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Objective: Bladder cancer (BCa) is the fifth most common cancer and the second most common urinary tract cancer in worldwide. BCa accounts for 3% of all cancers and is particularly common in developed countries. Material and methods: Eighteen of the 20 patients included in the study were male, 2 were female, mean age was 65.1±12.1(range:37-75) years. The control group consisted of 19 male one female, mean age was 60.3±11.2 (range:40-70) years. A total of seven miRNAs, let-7c, miR-155, miR-125b, miR-141 miR-145, miR 181 and miR 192 were evaluated in two groups. Results: MiRNAs of bladder cancer patients and healthy individuals were compared according to endogenous miR 181 and miR 192 Delta CT values, miR125b values of bladder cancer cases were found to be significantly higher than healthy controls.(p=0.021) In our study, miR125b, which we found specific and sensitive in endogenous controls, was compatible with studies in the literature. As conclusion, we emphasize that mir125b can be used as a predictor in bladder cancer compared with the literature.