The importance of MicroRNA 106b as a biomarker in gastric cancer
Coşkun, Hasan Şenol
Göksu, Sema Sezgin
Aktekin, Mehmet Rıfkı
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Objective: Gastric cancer (GC) is the fourth most common malignant disease worldwide, and it is observed 2-3 times more frequently in men than in women. It is important to make an early diagnosis in GC, by using screening methods such as serological markers and histological precursor. MiRNAs circulating in the blood have come to the fore in the early diagnosis of GC. In this study, our aim was to detect the most specific and sensitive microRNA by studying the microRNAs in the patient and control groups. Material and methods: Fourteen patients diagnosed with gastric cancer and fourteen healthy individuals of the same age and gender were selected as the control group. Three miRNAs (miR-34a, miR106b, miR-223 and miR 181 and miR 192 used as the endogenous control group in line with their binding potentials and gene expression levels. Results: Only miR106b was upregulated and statiscally important compared with the endogenous control miR181 for patients and healthy individuals (p:0.022). Conclusion: MiR-106b may have an important role in both the early diagnosis. Further extensive studies are needed.