The role of Kallikrein10 (KLK10) polymorphism in prostate cancer susceptibility
Tarih
2021Yazar
Güleç Yılmaz, Seda
Yenilcek, Faruk
Yıldırım, Asıf
Akdeniz, Fatma Tuba
Dalan, Altay Burak
Barut, Zerrin
İsbir, Turgay
Üst veri
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Purpose: The present study aims to investigate the potential role of Kallikrein 10 (KLK10) genotype and allele frequencies in predisposition to prostate cancer. Materials and methods: KLK10 (rs7259451) gene polymorphisms were determined by real-time polymerase chain reaction analysis in patients with prostate cancer (n=69) and controls (n=76). Results: KLK10 gene frequencies were significantly different in the case and control groups (P = .028). GG carriers were significantly higher in the control group (P = .034), whereas TT carriers were higher in the prostate cancer group (P = .033). Furthermore, The patients with GG genotype had the lowest PSA levels while TT carriers had the highest (P = .005). Conclusion: According to the results, we suggested that carrying variant T allele and also carrying homozygote TT genotype could be a potential risk, while ancestral homozygote GG genotype and G allele are risk reducing factors for prostate cancer.