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dc.contributor.authorKostak, Feyza
dc.contributor.authorKerbouche, Omar
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorDemirel Topel, Seda
dc.date.accessioned2022-04-25T11:55:06Z
dc.date.available2022-04-25T11:55:06Z
dc.date.issued2021
dc.identifier.citationKostak, F., Kerbouche, O., Pehlivanoglu, S. & Demirel Topel, S. (2021). Bodipy photosensitizer linked hybrid nanomaterials for photodynamic therapy. Advanced Nanomaterials Congress 2021.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12566/1174
dc.description.abstractPhotodynamic therapy (PDT) is an alternative clinically approved treatment method to obliterate the cancerous lesion by producing reactive oxygen species (ROS) via activated photosensitizer (PS) molecule at a certain wavelength1. In recent years, Bodipy (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) as a photosensitizer molecule has been extensively investigated in PDT2,3. However, the use of many Bodipy PS in PDT has been limited due to their insolubility in aqueous solutions. Therefore, nanotechnology offers tremendous solutions to building up nano-carrier systems for insoluble molecules. We have herein developed a stable formulation of hybrid Bodipy PS via conjugation of TiO2 nanoparticles to the Bodipy PS. In this study, a heavy metal substituted Bodipy PS molecule has been synthesized and linked to polyethyleneimine (PEI) functionalized TiO2 nanoparticles to increase the stability and biocompatibility of the photosensitizer in physiological conditions (pH:7.4) as a potential photodynamic therapy agent and investigated PDT effect on CRL-4010 and MDA-MB-231 cancer cells.en_US
dc.description.sponsorshipNo sponsoren_US
dc.language.isoengen_US
dc.publisherAdvanced Nanomaterials Congressen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTiO2en_US
dc.subjectBodipyen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectFotodinamik terapitr_TR
dc.subjectAnti-cancer activityen_US
dc.subjectKanser karşıtı aktivitetr_TR
dc.subjectColony formationen_US
dc.subjectKoloni oluşumutr_TR
dc.titleBodipy photosensitizer linked hybrid nanomaterials for photodynamic therapyen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.relation.publicationcategoryInternational publicationen_US
dc.contributor.orcid0000-0002-0567-5627 [Demirel Topel, Seda]
dc.contributor.abuauthorDemirel Topel, Seda
dc.contributor.yokid280190 [Demirel Topel, Seda]
dc.contributor.ScopusAuthorID55225915900 [Demirel Topel, Seda]


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