-
Adverse biological effects of ingested polystyrene microplastics using Drosophila melanogaster as a model in vivo organism
Demir, Eşref (Journal of Toxicology and Environmental Health, Part A: Current Issues, 2021)The abundant presence and extensive use of polystyrene microplastics (PSMPs) has recently become a serious environmental concern, as impact of exposure to these substances on human health remains unknown. While in vitro ... -
A comprehensive in vivo study using drosophila melanogaster: new insights into mechanisms and biological effects of permethrin nanopesticides
Demir, Eşref; Kansız, Seyithan; Doğan, Mehmet; Topel, Önder; Akkoyunlu, Gökhan; Kandur, Muhammed Yusuf (The 6th ed. of the International Conference Nanotech France 2021, 2021) -
Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays
Demir, Eşref; Qin, Taichun; Li, Yan; Zhang, Yongbin; Guo, Xiaoqing; Ingle, Taylor; Yan, Jian; Orza, Annamaria Ioana; Biris, Alexandru S.; Ghorai, Suman; Zhou, Tong; Chen, Tao (Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2020)Cadmium oxide nanoparticles (CdO NPs) are among some of the most studied and industrially used metal oxide NPs. They have been widely used for industrial application, such as paint pigments and electronic devices, and ... -
Drosophila as a model for assessing nanopesticide toxicity
Demir, Eşref (Nanotoxicology, 2020)One of the fastest-moving fields in today’s world of applied science, nanotechnology allows the control and design of matter on an extremely small scale, so it has now become an integral part of various industries and ... -
Drosophila as a robust model system for assessing autophagy: a review
Demir, Eşref; Kacew, Sam (Toxics, 2023)Autophagy is the process through which a body breaks down and recycles its own cellular components, primarily inside lysosomes. It is a cellular response to starvation and stress, which plays decisive roles in various ... -
Drosophila as a suitable in vivo model in the safety assessment of nanomaterials
Demir, Eşref; Turna Demir, Fatma; Marcos, Ricard (Springer Cham, 2022)Nanotechnology is often praised as the future technology that will revolutionize the world as we know it, because nanomaterials (NMs) offer numerous practical applications for a wide range of fields such as medicine, ... -
Drosophila melanogaster as a dynamic in vivo model organism reveals the hidden effects of interactions between microplastic/nanoplastic and heavy metals
Demir, Eşref; Turna Demir, Fatma (Journal of Applied Toxicology, 2022)Plastic waste in different environments has been constantly transforming into microplastic/nanoplastic (MNPLs). As they may coexist with other contaminants, they may behave as vectors that transport various toxic trace ... -
Drosophila: a promising model for evaluating the toxicity of environmental pollutants
Demir, Eşref; Turna Demir, Fatma (Karaelmas Fen ve Mühendislik Dergisi, 2022)Environmental contamination has now become a major global issue with adverse effects on our health and food security. Humans and animals are being exposed to debilitating levels of contamination on a daily basis. Across ... -
Environmental toxicology and human health
Demir, Eşref; Kacew, Sam (Multidisciplinary Digital Publishing Institute, 2024) -
Exposure to boron trioxide nanoparticles and ions cause oxidative stress, DNA damage, and phenotypic alterations in Drosophila melanogaster as an in vivo model
Turna Demir, Fatma; Demir, Eşref (Journal of Applied Toxicology, 2022)Boron trioxide nanoparticles (B2O3 NPs) have recently been widely used in a range of applications including electronic device technologies, acousto-optic apparatus fields, and as nanopowder for the production of special ... -
Genotoxicity mechanism of food preservative propionic acid in the in vivo Drosophila model: gut damage, oxidative stress, cellular immune response and DNA damage
Turna Demir, Fatma; Demir, Eşref (Informa Healthcare, 2022)Propionic acid is a short-chain fatty acid that is the main fermentation product of the enteric microbiome. It is found naturally and added to foods as a preservative and evaluated by health authorities as safe for use in ... -
Grafen ve çok duvarlı karbon nanotüplerinin drosophila melanogaster (meyve sineği)'de parazitoid direnci, hücresel immün direnç ve nanogenotoksisite mekanizmaları üzerine etkilerinin araştırılması
Demir, Eşref (Antalya Bilim Üniversitesi, 2020) -
Hazard assessment of the effects of acute and chronic exposure to permethrin, copper hydroxide, acephate, and validamycin nanopesticides on the physiology of drosophila: novel insights into the cellular internalization and biological effects
Demir, Eşref; Kansız, Seyithan; Doğan, Mehmet; Topel, Önder; Akkoyunlu, Gökhan; Kandur, Muhammed Yusuf; Turna Demir, Fatma (International Journal of Molecular Sciences, 2022)New insights into the interactions between nanopesticides and edible plants are required in order to elucidate their impacts on human health and agriculture. Nanopesticides include formulations consisting of organic/inorganic ... -
In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of drosophila melanogaster larval brain
Turna Demir, Fatma; Demir, Eşref (Journal of Applied Toxicology, 2023)Agriculture commonly utilizes crop protection products to tackle infestations from fungi, parasites, insects, and weeds. Validamycin A, an inhibitor of trehalase, possesses antibiotic and antifungal attributes. Epidemiological ... -
In vivo evaluation of the toxic and genotoxic effects of exposure to cobalt nanoparticles using Drosophila melanogaster
Alaraby, Mohamed; Demir, Eşref; Domenech, Josefa; Velázquez, Antonia; Hernández, Alba; Marcos, Ricard (Environmental Science Nano, 2020)Nanomaterials in general and cobalt nanoparticles (CoNPs) in particular are of great interest not only because of their multiple applications and environmental impact, but also for their potential toxicity and safety issues. ... -
An in vivo study of nanorod, nanosphere, and nanowire forms of titanium dioxide using Drosophila melanogaster: toxicity, cellular uptake, oxidative stress, and DNA damage
Demir, Eşref (Journal of Toxicology and Environmental Health, Part A, 2020)The biological impact of nanomaterials (NMs) is determined by several factors such as size and shape, which need to be taken into consideration in any type of analysis. While investigators often prefer to conduct in vitro ... -
Independent effects on cellular and humoral immune responses underlie genotype-by- genotype interactions between Drosophila and parasitoids
Leitão, Alexandre B.; Bian, Xueni; Day, Jonathan P.; Pitton, Simone; Demir, Eşref; Jiggins, Francis M. (PLoS Pathogens, 2019)It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects ... -
Interactions of graphene oxide and graphene nanoplatelets with the in vitro Caco-2/HT29 model of intestinal barrier
Domenech, Josefa; Hernández, Alba; Demir, Eşref; Marcos, Ricard; Cortés, Constanza (Scientific Reports, 2020)Carbon-based nanomaterials are being increasingly used, demanding strong information to support their safety in terms of human health. As ingestion is one of the most important exposure routes in humans, we have determined ... -
Interactions of ingested polystyrene microplastics with heavy metals (cadmium or silver) as environmental pollutants: a comprehensive in vivo study using drosophila melanogaster
Turna Demir, Fatma; Akkoyunlu, Gökhan; Demir, Eşref (Biology, 2022)Living organisms are now constantly exposed to microplastics and nanoplastics (MNPLs), and besides their toxic potential, they can also act as carriers of various hazardous elements such as heavy metals. Therefore, this ... -
Mechanisms and biological impacts of graphene and multi-walled carbon nanotubes on Drosophila melanogaster: Oxidative stress, genotoxic damage, phenotypic variations, locomotor behavior, parasitoid resistance, and cellular immune response
Demir, Eşref (Journal Of Applied Toxicology, 2021)The use of graphene and multi-walled carbon nanotubes (MWCNTs) has now become rather common in medical applications as well as several other areas thanks to their useful physicochemical properties. While in vitro testing ...
