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dc.contributor.authorDemirkol Canlı, Seçil
dc.contributor.authorÜner, Meral
dc.contributor.authorKüçükkaraduman, Barış
dc.contributor.authorKaraoğlu, Diren Arda
dc.contributor.authorIşık, Aynur
dc.contributor.authorTurhan, Nesrin
dc.contributor.authorAkyol, Aytekin
dc.contributor.authorGömceli, İsmail
dc.contributor.authorGüre, Ali Osmay
dc.date.accessioned2024-04-16T10:18:10Z
dc.date.available2024-04-16T10:18:10Z
dc.date.issued2023
dc.identifier.citationDemirkol Canlı, S., Üner, M., Küçükkaraduman, B., Karaoğlu, D. A., Işık, A., Turhan, N., Akyol, A., Gömceli, İ. & Güre, A. O. (2023). A novel gene list identifies tumors with a stromal-mesenchymal phenotype and worse prognosis in gastric cancer. Cancers, 15(11).en_US
dc.identifier.otherPMC10252086
dc.identifier.urihttp://hdl.handle.net/20.500.12566/2093
dc.description.abstractBackground: Molecular biomarkers that predict disease progression can help identify tumor subtypes and shape treatment plans. In this study, we aimed to identify robust biomarkers of prognosis in gastric cancer based on transcriptomic data obtained from primary gastric tumors. Methods: Microarray, RNA sequencing, and single-cell RNA sequencing-based gene expression data from gastric tumors were obtained from public databases. Freshly frozen gastric tumors (n = 42) and matched FFPE (formalin-fixed, paraffin-embedded) (n = 40) tissues from a Turkish gastric cancer cohort were used for quantitative real-time PCR and immunohistochemistry-based assessments of gene expression, respectively. Results: A novel list of 20 prognostic genes was identified and used for the classification of gastric tumors into two major tumor subgroups with differential stromal gene expression (“Stromal-UP” (SU) and “Stromal-DOWN” (SD)). The SU group had a more mesenchymal profile with an enrichment of extracellular matrix-related gene sets and a poor prognosis compared to the SD group. Expression of the genes within the signature correlated with the expression of mesenchymal markers ex vivo. A higher stromal content in FFPE tissues was associated with shorter overall survival. Conclusions: A stroma-rich, mesenchymal subgroup among gastric tumors identifies an unfavorable clinical outcome in all cohorts tested.en_US
dc.description.sponsorshipNo sponsoren_US
dc.language.isoengen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric canceren_US
dc.subjectMide kanseritr_TR
dc.subjectPrognosisen_US
dc.subjectPrognoztr_TR
dc.subjectBiomarkeren_US
dc.subjectBiyobelirteçtr_TR
dc.subjectStromaen_US
dc.subjectStromatr_TR
dc.titleA novel gene list identifies tumors with a stromal-mesenchymal phenotype and worse prognosis in gastric canceren_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.relation.publicationcategoryInternational publicationen_US
dc.identifier.wosWOS:001005954200001
dc.identifier.scopus2-s2.0-85161365644
dc.identifier.volume15
dc.identifier.issue11
dc.contributor.orcid0000-0001-6734-1254 [Gömceli, İsmail]
dc.contributor.abuauthorGömceli, İsmail
dc.contributor.yokid218994 [Gömceli, İsmail]
dc.relation.journalCancersen_US
dc.contributor.ScopusAuthorID6507091009 [Gömceli, İsmail]
dc.identifier.PubMedID37296997
dc.identifier.doi10.3390/cancers15113035


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