The role of microRNAs as biomarker in pancreas cancer

Abstract

Objective: Pancreatic cancer (PC) is an aggressive cancer of the digestive tract Overall survival for patients with pancreatic cancer is poor mainly due to the lack of biomarkers that enable early diagnosis. Several studies have shown that miRNAs can act as potential biomarkers of PC. Our aim in this study was to investigate microRNAs as a biomarker in the early diagnosis of PC. Patients and method: Nine patients diagnosed with pancreas cancer and nine healthy individuals of the same age and gender were selected as the control group. Six miRNAs (let-7c, miR-34a miR-125b, miR-141, miR-145, miR-155) selected and MiR 181 and miR 192 used as the endogenous control group. Results: In our study, when compared with endogenous controls, Mir125b was found to be significantly upregulated, while Mir141 was found to be significantly downregulated. As conlusion; Mir125b and MiR-141 may have an important role in