• English
    • Türkçe
  • Türkçe 
    • English
    • Türkçe
  • Giriş
Öğe Göster 
  •   E-arşiv Ana Sayfası
  • Akademik Arşiv / Institutional Repository
  • Diş Hekimliği Fakültesi / Faculty of Dentistry
  • Temel Tıp Bilimleri Tıbbi Biyokimya Anabilim Dalı / Basic Medical Sciences Department of Medical Biochemistry
  • Öğe Göster
  •   E-arşiv Ana Sayfası
  • Akademik Arşiv / Institutional Repository
  • Diş Hekimliği Fakültesi / Faculty of Dentistry
  • Temel Tıp Bilimleri Tıbbi Biyokimya Anabilim Dalı / Basic Medical Sciences Department of Medical Biochemistry
  • Öğe Göster
JavaScript is disabled for your browser. Some features of this site may not work without it.

Investigation of catechol-o-methyltransferase (comt) gene Val158Met polymorphism in ovarian cancer

Thumbnail
Göster/Aç
Investigation of catechol-o-methyltransferase (comt) gene Val158Met polymorphism in ovarian cancer (162.5Kb)
Tarih
2021
Yazar
Abaoğlu, İpek Yağmur
Güleç Yılmaz, Seda
Akdeniz, Fatma Tuba
Attar, Rukset
Barut, Zerrin
Dalan, Altay Burak
İsbir, Turgay
Üst veri
Tüm öğe kaydını göster
Özet
Objective: Catechol-o-methyltransferase (comt), the product of the COMT gene, detoxifies the carcinogenic catechol estrogens. The aim of the present study was to examine the relationship between comt Val158Met polymorphism and the risk of ovarian cancer. Material and methods: The study groups consist of 94 individuals as a patients group with ovarian cancer (n=47) and control group (n=47). The allele and genotype frequencies were determined according to Hardy-Weinberg equilibrium (HWE). The allele and genotype frequencies. determined according to HWE. Genetic analysis were performed by real-time-polymerase chain reaction instrument, and the statistical analysis were performed by SPSS program. Results: Although no significant relationship was obtained among groups (p=0.413) regarding comt gene Val158Met polymorphism, the genotype frequencies for comt Val158Met (rs4860) polymorphism in groups was homozygote wild type GG genotype 25.5%, heterozygote GA genotype 46.8%, homozygote mutant AA genotype 27.7%. Conclusion: This study is the first to investigate the relationship between ovarian cancer and the Val158Met polymorphism in the comt gene in a Turkish population. No statistically significant relationship was identified among genotypes belonging to the patient and control groups although sample sizes were relatively small and the analysis should be repeated in a larger cohort.
Bağlantı
http://hdl.handle.net/20.500.12566/1197
Koleksiyonlar
  • Temel Tıp Bilimleri Tıbbi Biyokimya Anabilim Dalı / Basic Medical Sciences Department of Medical Biochemistry

DSpace software copyright © 2002-2016  DuraSpace
İletişim | Geri Bildirim
Theme by 
Atmire NV
 

 




sherpa/romeo


Göz at

Tüm E-arşivBölümler & KoleksiyonlarTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreABU Yazarına GöreWOSScopusPubMedTRDizinErişimBu KoleksiyonTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreABU Yazarına GöreWOSScopusPubMedTRDizinErişim

Hesabım

GirişKayıt

DSpace software copyright © 2002-2016  DuraSpace
İletişim | Geri Bildirim
Theme by 
Atmire NV
 

 


|| Kütüphane || Antalya Bilim Üniversitesi || OAI-PMH ||

Antalya Bilim Üniversitesi Kütüphane ve Dokümantasyon Müdürlüğü, Antalya, Turkey
İçerikte herhangi bir hata görürseniz, lütfen bildiriniz: acikerisim@antalya.edu.tr

E-arşiv@AntalyaBilim:


DSpace 6.4-SNAPSHOT

Gemini Bilgi Teknolojileri A.Ş tarafından destek verilmektedir.