http://hdl.handle.net/20.500.12566/560 Sun, 05 Apr 2026 22:45:08 GMT 2026-04-05T22:45:08Z http://hdl.handle.net/20.500.12566/2094 KEPAN Enteral Beslenme (EB) rehberi Doğanay, Mutlu; Akçay, Kezban; Çil, Timuçin; Dağ, Birgül; Demirağ, Kubilay; Demirkan, Salih Kutay; Gündoğdu, Rıza Haldun; Gündüz, Hasan Murat; Parsak, Cem Kaan; Topçuoğlu, Mehmet Akif; Türkoğlu, Melda; Abbasoğlu, Osman Beslenme desteği, hasta tedavisinin ayrılmaz bir parçasıdır. Bununla birlikte, günlük uygulamalarda beslenme tedavisi hedeflerine ulaşıldığını söylemek zordur. Bu nedenle klinik pratikte beslenme tedavisi uygulamalarını kolaylaştırmaya yönelik girişimlere ihtiyaç vardır. Malnütrisyon tedavisinde ilk seçenekler diyet düzenlemesi ve oral tamamlayıcı nütrisyon ürünleri kullanımıdır. Ancak oral yolla beslenemeyen veya beslenme hedeflerine ulaşılamayan bazı hasta gruplarında tüple beslenme ihtiyacı gerekmektedir. Tüm dünyada tıp fakültesi, beslenme ve diyetetik fakültesi ve uzmanlık eğitimi müfredatları klinik beslenme konusunda genellikle yeterli değildir. Hekim, diyetisyen, hemşire, eczacı ve diğer sağlık profesyonellerine yönelik, enteral beslenme kullanım endikasyonları, uygulanma şekilleri, ürünlerin seçimi, hasta izlemi, komplikasyonların yönetimi ve tedavi sonlandırılmasında yol gösterecek kısa, net ve pratik önerilere odaklı bir rehberin yararlı olacağını düşündük. Bu rehber, alanında deneyimli uzman bir ekip tarafından KEPAN çatısı altında hazırlanmış ve 29 kişiden oluşan KEPAN rehber grubunca onaylanmıştır. Sun, 01 Jan 2023 00:00:00 GMT http://hdl.handle.net/20.500.12566/2094 2023-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/2093 A novel gene list identifies tumors with a stromal-mesenchymal phenotype and worse prognosis in gastric cancer Demirkol Canlı, Seçil; Üner, Meral; Küçükkaraduman, Barış; Karaoğlu, Diren Arda; Işık, Aynur; Turhan, Nesrin; Akyol, Aytekin; Gömceli, İsmail; Güre, Ali Osmay Background: Molecular biomarkers that predict disease progression can help identify tumor subtypes and shape treatment plans. In this study, we aimed to identify robust biomarkers of prognosis in gastric cancer based on transcriptomic data obtained from primary gastric tumors. Methods: Microarray, RNA sequencing, and single-cell RNA sequencing-based gene expression data from gastric tumors were obtained from public databases. Freshly frozen gastric tumors (n = 42) and matched FFPE (formalin-fixed, paraffin-embedded) (n = 40) tissues from a Turkish gastric cancer cohort were used for quantitative real-time PCR and immunohistochemistry-based assessments of gene expression, respectively. Results: A novel list of 20 prognostic genes was identified and used for the classification of gastric tumors into two major tumor subgroups with differential stromal gene expression (“Stromal-UP” (SU) and “Stromal-DOWN” (SD)). The SU group had a more mesenchymal profile with an enrichment of extracellular matrix-related gene sets and a poor prognosis compared to the SD group. Expression of the genes within the signature correlated with the expression of mesenchymal markers ex vivo. A higher stromal content in FFPE tissues was associated with shorter overall survival. Conclusions: A stroma-rich, mesenchymal subgroup among gastric tumors identifies an unfavorable clinical outcome in all cohorts tested. Sun, 01 Jan 2023 00:00:00 GMT http://hdl.handle.net/20.500.12566/2093 2023-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/2092 Safe resection of gastrointestinal stromal tumor adjacent to the esophagogastric junction: Endoscopic transgastric wedge resection Yavuz, Rıdvan; Aras, Orhan; Çiyiltepe, Hüseyin; Çakır, Tebessüm; Gömceli, İsmail Introduction: Gastrointestinal (GI) tumors are submucosal lesions with malignant potential, most commonly found in the stomach. Materials and Methods: Between 2017 and 2023, patients with a pre-diagnosis of GI stromal tumors (GISTss) located adjacent to the gastroesophageal junction, exophytic growth into the stomach and masses below 5 cm were excised with endoscopic stapler placed transgastrically under endoscopic vision. The gender, age, length of hospitalization, post-operative complications, and pathology results of the patients were recorded retrospectively. Results: 58 patients with a pre-diagnosis of GIST were operated. 19 of them were located adjacent to the esophagogastric junction. 2 of 19 patients underwent total gastrectomy and 3 underwent proximal gastrectomy. 14 patients underwent transgastric resection and 2 of these patients were excluded from the study because the pathology result could not be GIST. No signifcant complications were observed in any of the 12 patients included in the study. Conclusion: Transgastric wedge resection under endoscopic visualization is a safe and organ-sparing surgical method for GISTs below 5 cm located adjacent to the esophagogastric junction. Sun, 01 Jan 2023 00:00:00 GMT http://hdl.handle.net/20.500.12566/2092 2023-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/1929 A grounded theory of resilience experiences of women with gynecological cancer Oruç, Mine; Deliktaş Demirci, Ayşe; Kabukcuoğlu, Kamile Purpose: The present study aims to develop an explanatory framework ot gain a deeper understanding of the resilience process in women diagnosed with gynecological cancers. Method: Informed by Salutogenesis Model, a Straussian-grounded theory study was conducted. In-depth ni- terviews were conducted with 20 women with gynecological cancer between January and August 2022. Data were analyzed using open, axial, selective coding, and constant comparative methods. Results: The core category encapsulated that most women defined resilience as having a dynamic process that could be promoted throughout the process. However, they expressed that they needed "individual resources for resilience" and "generated resources by the supportive interventions" to be resilient. They emphasized that these resources should make the process manageable, meaningful, and comprehensible to promote resilience. Furthermore, they defined ni detail which components should be included ni supportive interventions. They stated "some reflections of resilience on their cancer process" and life gains from the proces." Conclusion: This study developed agrounded theory that provides aguideline for healthcare professionals on how women could be encouraged to have resilience and what is the importance of resilience on women's cancer process and their lives. Salutogenesis may help to understand the resilience process in women with gynecological cancer and provides direction for how healthcare professionals should shape their clinical interventions to promote the resilience process. Thu, 01 Jun 2023 00:00:00 GMT http://hdl.handle.net/20.500.12566/1929 2023-06-01T00:00:00Z