http://hdl.handle.net/20.500.12566/555 2026-07-22T11:34:35Z http://hdl.handle.net/20.500.12566/2493 Determination of neutron and gamma ray shielding properties, secondary radiation formations and neutron damage of composites containing polyester/pyrite/titanium diboride Turhan, Mehmet Fatih; Kaçal, Mustafa Recep; Özdoğan, Hasan; Turşucu, Ahmet; Akman, Ferdi; Oğul, Hasan; Polat, Hasan; Yurtcan, Sinem Composite materials comprising titanium diboride (TiB2), unsaturated polyester resin, and pyrite (FeS2) at varying weight percentages were fabricated and evaluated for their interaction with neutron and gamma radiation. This study adopts a comprehensive methodology, combining theoretical calculations, experimental measurements, and Monte Carlo simulations using PHITS and MCNP6. A strong correlation was observed among experimental results, WinXCOM data, and simulation outputs, with discrepancies remaining within approximately 5 %. To assess neutron shielding performance, fast neutron removal cross sections and partial neutron transmission rates were determined for both fast and thermal neutron energies, as well as across varying sample thicknesses. Additionally, secondary radiation effects were analyzed by quantifying the number and average energy of secondary neutrons and gamma photons generated from interactions with thermal and fast neutrons. Radiation damage parameters, including Total Ionizing Dose (TID) and Displacement Per Atom (DPA), were also evaluated. Gamma-ray shielding performance was assessed through experimental measurements, theoretical models, and Monte Carlo simulations, focusing on key parameters such as mass attenuation coefficients, kerma relative to air and concrete, and buildup factors. Among the composites, the sample labeled FeSTiB-50 demonstrated superior fast neutron attenuation capability—outperforming conventional concrete and approaching the shielding efficiency of paraffin—while all composites exhibited excellent attenuation of thermal neutrons. Furthermore, the FeSTiB-50 composite generated secondary radiation with lower average energy compared to other samples. However, the gamma-ray shielding performance was found to decrease with increasing TiB2 content, indicating a trade-off between neutron and gamma shielding effectiveness. 2025-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/2414 Dosimetric comparison of field-in-field and intensity-modulated radiotherapy techniques in bilateral breast cancer radiotherapy Bilgiç, Erdi; Karakoç, Melike; Öğüt, Selim; Çoker, Eylem Gülce Aim: This study aims to compare the dosimetric parameters, treatment efficiency, and organ-at-risk (OAR) sparing between field-in-field (FinF) and intensity-modulated radiotherapy (IMRT) techniques in the treatment of bilateral breast cancer. Method: Radiotherapy treatment plans were developed for 10 patients diagnosed with bilateral breast cancer using both FinF and IMRT techniques. Dosimetric parameters, including Dmax, V47.5, V46, D2, D50, and D98 for target volumes, were evaluated. Conformity index (CI) and homogeneity index (HI) were also assessed. Additionally, OAR doses were compared to determine the advantages and disadvantages of each technique. All plans were evaluated in accordance with international standards and quality control protocols. Results: Both techniques achieved clinically acceptable dose distributions. FinF plans demonstrated lower OAR doses and were more advantageous in terms of treatment time, number of fields, and segment count. Conversely, IMRT plans provided superior dose homogeneity and target coverage. Although IMRT required longer planning and treatment times due to higher segment numbers, OAR doses remained within acceptable limits and were consistent with the literature. Conclusion: The FinF technique remains a viable and efficient option in bilateral breast cancer radiotherapy, particularly in reducing OAR doses and treatment duration. However, IMRT offers better conformity and dose homogeneity, making it preferable when precise dose distribution is prioritized. Selection of the appropriate technique should be patient-specific, balancing clinical priorities and resource availability.; Amaç: Bu çalışmanın amacı, bilateral meme kanseri tedavisinde kullanılan alan içinde alan (FinF) ve yoğunluk ayarlı radyoterapi (YART/IMRT) tekniklerinin dozimetrik parametreler, tedavi etkinliği ve risk altındaki organların (RAO) korunması açısından karşılaştırılmasıdır. 2025-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/2413 The future role of nanoparticles in radiation therapy Tunçel, Nina; Bilgiç, Erdi Çakır, Tahir; Tunçel, Nina This comprehensive book delves into the latest advancements in radiotherapy, offering an in-depth exploration of groundbreaking techniques poised to revolutionize cancer treatment. Image-Guided Radiation Therapy (IGRT) leverages advanced imaging technology to precisely target tumors during sessions. Integrating PET imaging, Biology-Guided Radiation Therapy (BGRT) represents a cutting-edge approach in cancer treatment. Beyond photons, electrons, and protons, Boron Neutron Capture Therapy (BNCT) introduces a novel perspective on particle use. Key innovations such as Flash-RT, radiomic features, immunotherapy, and nanoparticles are meticulously examined, showcasing their potential to enhance treatment precision and efficacy. This book provides a thorough overview of these innovative approaches, contributing to the ongoing evolution of radiotherapy. The artificial intelligence is also highlighted, emphasizing its role in accelerating progress and achieving goals. It is an essential resource for clinicians, researchers, and students aiming to stay at the forefront of cancer treatment advancements. Adopting new technologies and methodologies greatly enhances cancer patient outcomes worldwide and expands the possibilities in radiotherapy. 2024-01-01T00:00:00Z http://hdl.handle.net/20.500.12566/2393 The relationship between diabetes and myricetin: Bibliometric study Özcan, Filiz; Hangül, Ceren; Özdoğan, Hasan Myricetin is an active flavonoid compound known for its beneficial effects in diabetes management. The objective of this study is to characterize the research landscape on myricetin and diabetes by identifying its principal features, emerging trends, and thematic focuses thereby clarifying the therapeutic role of myricetin within the broader diabetes research field. Through bibliometric analysis, this study aims to provide comprehensive data specified to diabetes and myricetin. Material and Methods: R package “Bibliometrix” software was used to perform bibliometric analysis. The analysis included descriptive statistics, scientific mapping, keyword co-occurrence, and network analysis to identify influential elements such as highly cited articles, leading authors and journals, productive countries, and collaborative patterns. Results: The analysis showed limited growth until 2009, followed by rapid expansion. Most documents were original research articles (82.8%), highlighting active data generation. Keyword co-occurrence revealed oxidative stress, flavonoids, polyphenols, antioxidant, and insulin resistance as dominant themes. Twelve clusters were identified, with oxidative stress/myricetin/antioxidant and flavonoids/insulin resistance/phenolic compounds most prominent. Knekt et al. was most globally cited, Ong et al. most locally cited. China, India, Brazil, the United States, and Korea led output, while Journal of Ethnopharmacology, Molecules, and Plants Basel were most productive. Conclusion: The findings reveal a expanding body of research on myricetin in the context of diabetes, with increasing global interest, strong collaborative networks, and a clear thematic emphasis on oxidative stress and flavonoid-related mechanisms. This bibliometric overview provides a structured map of the field and may guide future studies towards unexplored research gaps.; Myricetin, diyabetin yönetiminde faydalı etkileriyle bilinen doğal bir flavonoid bileşiğidir. Bu çalışmanın amacı, myricetin ve diyabet konusundaki araştırma alanını karakterize ederek temel özelliklerini, ortaya çıkan eğilimleri ve tematik odak noktalarını belirlemek, böylece myricetinin terapötik rolünü diyabet araştırmaları bağlamında ortaya koymaktır. Bibliyometrik analiz yoluyla bu alana özgü kapsamlı veriler sunulması hedeflenmiştir. Gereç ve Yöntemler: Bibliyometrik analiz, R tabanlı ''Bibliometrix'' yazılım paketi kullanılarak gerçekleştirilmiştir. Analiz kapsamında betimleyici istatistikler, bilimsel haritalama, anahtar kelime birliktelik analizi ve ağ analizleri yapılmış; en çok atıf alan makaleler, önde gelen yazarlar ve dergiler, üretken ülkeler ve iş birliği örüntüleri belirlenmiştir. Bulgular: Analiz sonuçları, 2009 yılına kadar sınırlı bir yayın artışı olduğunu, bu tarihten sonra ise hızlı bir yükselişin başladığını göstermiştir. Yayınların çoğunluğunu özgün araştırma makaleleri (%82.8) oluşturmakta olup, bu durum alanda aktif veri üretimini yansıtmaktadır. Anahtar kelime analizinde oksidatif stres, flavonoidler, polifenoller, antioksidan ve insülin direnci öne çıkan temalar olmuştur. Toplam 12 tematik küme belirlenmiş; özellikle oksidatif stres/myricetin/antioksidan ve flavonoidler/insülin direnci/fenolik bileşikler kümeleri en belirgin gruplar olarak saptanmıştır. En fazla atıf alan çalışma Knekt ve ark. (2002), en yüksek yerel atıf alan çalışma ise Ong ve ark. (1997) olmuştur. Ülke bazında Çin, Hindistan, Brezilya, ABD ve Kore öne çıkmış; en üretken dergiler Journal of Ethnopharmacology, Molecules ve Plants-Basel olarak belirlenmiştir. Sonuç: Elde edilen bulgular, artan küresel ilgi, güçlü iş birliği ağları ve oksidatif stres ile flavonoid mekanizmalarına odaklı temaların myricetin ve diyabet konusundaki araştırmaların hızla genişleyen bir alan olduğunu göstermektedir. Bu bibliyometrik inceleme, alana ilişkin yapısal bir bakış sunmakta ve gelecekteki araştırmalar için olası boşlukların belirlenmesine katkı sağlamaktadır.. 2025-01-01T00:00:00Z