http://hdl.handle.net/20.500.12566/804 2026-04-05T22:51:36Z 2026-04-05T22:51:36Z Bilgiç, Erdi Karakoç, Melike Öğüt, Selim Çoker, Eylem Gülce http://hdl.handle.net/20.500.12566/2414 2026-01-15T11:26:44Z 2025-01-01T00:00:00Z

Dosimetric comparison of field-in-field and intensity-modulated radiotherapy techniques in bilateral breast cancer radiotherapy Bilgiç, Erdi; Karakoç, Melike; Öğüt, Selim; Çoker, Eylem Gülce Aim: This study aims to compare the dosimetric parameters, treatment efficiency, and organ-at-risk (OAR) sparing between field-in-field (FinF) and intensity-modulated radiotherapy (IMRT) techniques in the treatment of bilateral breast cancer. Method: Radiotherapy treatment plans were developed for 10 patients diagnosed with bilateral breast cancer using both FinF and IMRT techniques. Dosimetric parameters, including Dmax, V47.5, V46, D2, D50, and D98 for target volumes, were evaluated. Conformity index (CI) and homogeneity index (HI) were also assessed. Additionally, OAR doses were compared to determine the advantages and disadvantages of each technique. All plans were evaluated in accordance with international standards and quality control protocols. Results: Both techniques achieved clinically acceptable dose distributions. FinF plans demonstrated lower OAR doses and were more advantageous in terms of treatment time, number of fields, and segment count. Conversely, IMRT plans provided superior dose homogeneity and target coverage. Although IMRT required longer planning and treatment times due to higher segment numbers, OAR doses remained within acceptable limits and were consistent with the literature. Conclusion: The FinF technique remains a viable and efficient option in bilateral breast cancer radiotherapy, particularly in reducing OAR doses and treatment duration. However, IMRT offers better conformity and dose homogeneity, making it preferable when precise dose distribution is prioritized. Selection of the appropriate technique should be patient-specific, balancing clinical priorities and resource availability.; Amaç: Bu çalışmanın amacı, bilateral meme kanseri tedavisinde kullanılan alan içinde alan (FinF) ve yoğunluk ayarlı radyoterapi (YART/IMRT) tekniklerinin dozimetrik parametreler, tedavi etkinliği ve risk altındaki organların (RAO) korunması açısından karşılaştırılmasıdır.

2025-01-01T00:00:00Z Tunçel, Nina Bilgiç, Erdi http://hdl.handle.net/20.500.12566/2413 2026-01-29T08:23:04Z 2024-01-01T00:00:00Z

The future role of nanoparticles in radiation therapy Tunçel, Nina; Bilgiç, Erdi Çakır, Tahir; Tunçel, Nina This comprehensive book delves into the latest advancements in radiotherapy, offering an in-depth exploration of groundbreaking techniques poised to revolutionize cancer treatment. Image-Guided Radiation Therapy (IGRT) leverages advanced imaging technology to precisely target tumors during sessions. Integrating PET imaging, Biology-Guided Radiation Therapy (BGRT) represents a cutting-edge approach in cancer treatment. Beyond photons, electrons, and protons, Boron Neutron Capture Therapy (BNCT) introduces a novel perspective on particle use. Key innovations such as Flash-RT, radiomic features, immunotherapy, and nanoparticles are meticulously examined, showcasing their potential to enhance treatment precision and efficacy. This book provides a thorough overview of these innovative approaches, contributing to the ongoing evolution of radiotherapy. The artificial intelligence is also highlighted, emphasizing its role in accelerating progress and achieving goals. It is an essential resource for clinicians, researchers, and students aiming to stay at the forefront of cancer treatment advancements. Adopting new technologies and methodologies greatly enhances cancer patient outcomes worldwide and expands the possibilities in radiotherapy.

2024-01-01T00:00:00Z