Ara
Toplam kayıt 6, listelenen: 1-6
Chemogenomics and orthology‐based design of antibiotic combination therapies
(Molecular Systems Biology, 2016)
Combination antibiotic therapies are being increasingly used in
the clinic to enhance potency and counter drug resistance.
However, the large search space of candidate drugs and dosage
regimes makes the identification ...
Modeling the combined effect of RNA-binding proteins and microRNAs in post-transcriptional regulation
(Nucleic Acids Research, 2016)
Recent studies show that RNA-binding proteins (RBPs) and microRNAs (miRNAs) function in coordination with each other to control post-transcriptional regulation (PTR). Despite this, the majority of research to date has ...
Modeling gene regulation in liver hepatocellular carcinoma with random forests
(BioMed Research International, 2016)
Liver hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death. Poor understanding of the mechanisms underlying HCC prevents early detection and leads to high mortality. We developed a random forest ...
Inferring RBP-mediated regulation in lung squamous cell carcinoma
(Plos One, 2016)
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of mRNAs. Dysregulations in RBP-mediated mechanisms have been found to be associated with many steps of cancer initiation and progression. Despite ...
A comprehensive database of high-throughput sequencing-based RNA secondary structure probing data (structure surfer)
(BMC Bioinformatics, 2016)
Background: RNA molecules fold into complex three-dimensional shapes, guided by the pattern of hydrogen bonding between nucleotides. This pattern of base pairing, known as RNA secondary structure, is critical to their ...
Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
(Nature Communications, 2016)
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional ...