Toplam kayıt 54, listelenen: 35-54

    • Mechanisms and biological impacts of graphene and multi-walled carbon nanotubes on Drosophila melanogaster: Oxidative stress, genotoxic damage, phenotypic variations, locomotor behavior, parasitoid resistance, and cellular immune response 

      Demir, Eşref (Journal Of Applied Toxicology, 2021)
      The use of graphene and multi-walled carbon nanotubes (MWCNTs) has now become rather common in medical applications as well as several other areas thanks to their useful physicochemical properties. While in vitro testing ...
    • MicroRNAs as a biomarker in lung cancer 

      Canatan, Duran; Sönmez, Yonca; Yılmaz, Özlem; Coşkun, Hasan Şenol; Göksu, Sema Sezgin; Uçar, Selda; Aktekin, Mehmet Rıfkı (Mattioli, 2023)
      Introduction: Lung cancer (LC) is the most common cancer in the world.Well known causes are long term smoking, environmental influences and genetic variations. LC is divided into two main types based on their histological ...
    • The miR125b as biomarkers in the early diagnosis of bladder cancer 

      Canatan, Duran; Yılmaz, Özlem; Sönmez, Yonca; Baykara, Mehmet; Savaş, Murat; Coşkun, Hasan Şenol; Göksu, Sema Sezgin; Aktekin, Mehmet Rıfkı (Genetics & Molecular Medicine, 2022)
      Objective: Bladder cancer (BCa) is the fifth most common cancer and the second most common urinary tract cancer in worldwide. BCa accounts for 3% of all cancers and is particularly common in developed countries. Material ...
    • Nadir hastalıkların tanısında tüm genom analizi 

      Canatan, Duran; Çim, Abdullah; Bauer, Peter; Altunsoy, Emel; Güvercin Aldemir, Gözde (2022)
      Giriş: Nadir hastalıklar, görülme sıklığı 1/2000’den az olan hastalıklar olarak tanımlanır. Nadir hastalıklar genellikle birden fazla sistemi etkileyen oldukça heterojen bir gruptur. Bunların yaklaşık %80’i genetik nedenlere ...
    • Novel insights into acute/chronic genotoxic impact of exposure to tungsten oxide nanoparticles on Drosophila melanogaster 

      Turna Demir, Fatma; Demir, Eşref (Journal of Nanoparticle Research, 2022)
      Tungsten oxide nanoparticles (WO3 NPs) have now been employed by various products including electronics, smart screens, gas-biosensors, water purifiers, disinfectants, and biomedical applications. Despite this wide-ranging ...
    • Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies 

      Shimizu, Kazuhide; Kahramanian, Andranik; Jabbar, Muzammil Arif Din Abdul; Turna Demir, Fatma; Gokyer, Dilan; Uthamacumaran, Abicumaran; Rajan, Anant; Saad, Mohammad Ahsan; Gorham, Joshua; Wakimoto, Hiroko; Martuza, Robert L.; Rabkin, Samuel D.; Hasan, Tayyaba; Wakimoto, Hiroaki (Cancer Letters, 2023)
      Oncolytic viruses (OVs) have emerged as a clinical therapeutic modality potentially effective for cancers that evade conventional therapies, including central nervous system malignancies. Rationally designed combinatorial ...
    • Potential genotoxic and biological effects of 1,4 dioxane on different model organisms 

      Turna Demir, Fatma; Demir, Eşref (Current Opinion in Environmental Science & Health, 2023)
      A suspected human carcinogen, the compound 1,4-dioxane (DXN) has been commonly employed as a solvent in the production of various cleaning applications, cosmetics, dyes, varnishes, waxes, and detergents. Leaked from ...
    • The potential use of drosophila as an in vivo model organism for COVID-19-related research: a review 

      Demir, Eşref (Turkish Journal of Biology, 2021)
      The world urgently needs effective antiviral approaches against emerging viruses, as shown by the coronavirus disease 2019 (COVID-19) pandemic, which has become an exponentially growing health crisis. Scientists from ...
    • Protective effects of resveratrol against genotoxicity induced by nano and bulk hydroxyapatite in Drosophila melanogaster 

      Turna Demir, Fatma (Journal of Toxicology and Environmental Health, 2022)
      Hydroxyapatite (HAp) is a naturally occurring calcium phosphate mineral predominantly used for its biocompatibility in a number of areas such as bone grafting, prosthesis coating in dentistry, and targeted drug delivery. ...
    • A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials 

      Demir, Eşref (Journal of applied Toxicology, 2021)
      Nanomaterials (NMs) generally display fascinating physical and chemical properties that are not always present in bulk materials; therefore, any modification to their size, shape, or coating tends to cause significant ...
    • The role of microRNAs as biomarker in pancreas cancer 

      Canatan, Duran; Sönmez, Yonca; Yılmaz, Özlem; Coşkun, Hasan Şenol; Göksu, Sema Sezgin; Uçar, Selda; Yıldırım, Bülent; Aktekin, Mehmet Rıfkı (Japanese Journal Gastroeneterology Research, 2022)
      Objective: Pancreatic cancer (PC) is an aggressive cancer of the digestive tract Overall survival for patients with pancreatic cancer is poor mainly due to the lack of biomarkers that enable early diagnosis. Several studies ...
    • A systematic in vivo study of copper hydroxide nanopesticides using Drosophila melanogaster: Cellular uptake and biological impacts 

      Demir, Eşref; Topel, Önder; Kansız, Seyithan; Akkoyunlu, Gökhan; Doğan, Mehmet; Kandur, Muhammed Yusuf (11th Congress of Toxicology in Developing Countries (CTDC11), 2021)
    • Talasemi genetiğinde zor olgular 

      Canatan, Duran (49. Ulusal Hematoloji Kongresi, 2023)
      Talasemi sendromları, hemoglobinleri oluşturan globin zincirlerinin (α, β, γ, δ) yetersiz sentez oranının önemli ölçüde azalması, böylece dengesiz zincir sentezine yol açması sonucunda, eritrosit öncüllerine zarar vererek ...
    • Talasemi ve hemoglobinopatilerde transfüzyon 

      Canatan, Duran (3. Azerbaycan Hematoloji Uzmanlar Kongresi, 2023)
      Giriş: Talasemi ve hemoglobinopatiler , hemoglobinleri oluşturan globin zincirlerinin (α, β, γ, δ) yetersiz sentez oranının önemli ölçüde azalması veya globin zincirlerinde yapısal bozukluklar oluşması sonucu eritrosit ...
    • Talasemide nereden nereye 

      Canatan, Duran (XVI. Ulusal Kan Merkezleri ve Transfüzyon Kongresi, 2023)
      Bu derlemede dünyada ve ülkemizde “Talasemide nereden nereye” gelindiğini, hem dünya hem ülkemizde önemli tarihi notlara değinerek özetleyeceğim. Dünya tarihine baktığımızda, talaseminin yüzyıllık öyküsü şöyledir. 1910 ...
    • Toxicity mechanisms of nanoparticles in the male reproductive system 

      Habas, Khaled; Demir, Eşref; Guo, Chongye; Brinkworth, Martin H; Anderson, Diana (Drug Metabolism Reviews, 2021)
      The field of nanotechnology has allowed for increasing nanoparticle (NP) exposure to the male reproductive system. Certain NPs have been reported to have adverse consequences on male germ and somatic cells. Germ cells are ...
    • Trimetilolpropan triakrilat’ın potansiyel toksik, genotoksik ve mutajenik etkilerinin drosophila melanogaster kullanılarak araştırılması 

      Turna Demir, Fatma (Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 2022)
      Trimetilolpropan triakrilat (TMPTA), mürekkepler, plastikler, ahşap ve metal kaplamalar gibi farklı malzeme ve formüllerde yaygın olarak kullanılan bir kimyasaldır. Birçok alanda yaygın olarak kullanılmasına rağmen bu ...
    • Bir Türk ailesinde Hb Andrew - Minneapolis varyantı 

      Sümter, Hamza; Mızrak, Soycan; Ceylaner, Serdar; Canatan, Duran (49. Ulusal Hematoloji Kongresi, 2023)
      Bugüne kadar toplam 1864 hemoglobin yapısal varyantı tanımlanmıştır. Hb Andrew-Minneapolis, beta zincirinin 144. pozisyondaki lizinin asparagin ile yer değiştirmesiyle oluşan bir beta zincir varyantıdır (HGVS adı ...
    • Use of MicroRNAs as biomarkers in the early diagnosis of prostate cancer 

      Canatan, Duran; Yılmaz, Özlem; Sönmez, Yonca; Çim, Abdullah; Baykara, Mehmet; Savaş, Murat; Coşkun, Hasan Şenol; Göksu, Sema Sezgin; Aktekin, Mehmet Rıfkı
      Introduction: Prostate cancer (PCa) is a common type of cancer in western countries and prominent cause of mortality in men. The aim of the study was to evaluate miRNAs as biomarkers in PCa in healthy individuals and ...
    • Warburg Cinotti sendromu: Ddr2 geninde De Novo 

      Hüseyinzade, Ayan; Çim, Abdullah; Bauer, Peter; Ceylaner, Serdar; Abay, Mehtap; Altunsoy, Emel; Güvercin Aldemir, Gözde; Canatan, Duran (2022)
      Giriş: Warburg-Cinotti sendromu (WRCN), otozomal dominant olarak kalıtılan çok nadir bir hastalıktır. WRCN ilerleyici kornea neovaskülarizasyonu, keloid oluşumu, kronik cilt ülserleri, deri altı doku kaybı, parmaklarda ...