http://hdl.handle.net/20.500.12566/555 2026-04-03T18:08:47Z 2026-04-03T18:08:47Z Bilgiç, Erdi Karakoç, Melike Öğüt, Selim Çoker, Eylem Gülce http://hdl.handle.net/20.500.12566/2414 2026-01-15T11:26:44Z 2025-01-01T00:00:00Z

Dosimetric comparison of field-in-field and intensity-modulated radiotherapy techniques in bilateral breast cancer radiotherapy Bilgiç, Erdi; Karakoç, Melike; Öğüt, Selim; Çoker, Eylem Gülce Aim: This study aims to compare the dosimetric parameters, treatment efficiency, and organ-at-risk (OAR) sparing between field-in-field (FinF) and intensity-modulated radiotherapy (IMRT) techniques in the treatment of bilateral breast cancer. Method: Radiotherapy treatment plans were developed for 10 patients diagnosed with bilateral breast cancer using both FinF and IMRT techniques. Dosimetric parameters, including Dmax, V47.5, V46, D2, D50, and D98 for target volumes, were evaluated. Conformity index (CI) and homogeneity index (HI) were also assessed. Additionally, OAR doses were compared to determine the advantages and disadvantages of each technique. All plans were evaluated in accordance with international standards and quality control protocols. Results: Both techniques achieved clinically acceptable dose distributions. FinF plans demonstrated lower OAR doses and were more advantageous in terms of treatment time, number of fields, and segment count. Conversely, IMRT plans provided superior dose homogeneity and target coverage. Although IMRT required longer planning and treatment times due to higher segment numbers, OAR doses remained within acceptable limits and were consistent with the literature. Conclusion: The FinF technique remains a viable and efficient option in bilateral breast cancer radiotherapy, particularly in reducing OAR doses and treatment duration. However, IMRT offers better conformity and dose homogeneity, making it preferable when precise dose distribution is prioritized. Selection of the appropriate technique should be patient-specific, balancing clinical priorities and resource availability.; Amaç: Bu çalışmanın amacı, bilateral meme kanseri tedavisinde kullanılan alan içinde alan (FinF) ve yoğunluk ayarlı radyoterapi (YART/IMRT) tekniklerinin dozimetrik parametreler, tedavi etkinliği ve risk altındaki organların (RAO) korunması açısından karşılaştırılmasıdır.

2025-01-01T00:00:00Z Tunçel, Nina Bilgiç, Erdi http://hdl.handle.net/20.500.12566/2413 2026-01-29T08:23:04Z 2024-01-01T00:00:00Z

The future role of nanoparticles in radiation therapy Tunçel, Nina; Bilgiç, Erdi Çakır, Tahir; Tunçel, Nina This comprehensive book delves into the latest advancements in radiotherapy, offering an in-depth exploration of groundbreaking techniques poised to revolutionize cancer treatment. Image-Guided Radiation Therapy (IGRT) leverages advanced imaging technology to precisely target tumors during sessions. Integrating PET imaging, Biology-Guided Radiation Therapy (BGRT) represents a cutting-edge approach in cancer treatment. Beyond photons, electrons, and protons, Boron Neutron Capture Therapy (BNCT) introduces a novel perspective on particle use. Key innovations such as Flash-RT, radiomic features, immunotherapy, and nanoparticles are meticulously examined, showcasing their potential to enhance treatment precision and efficacy. This book provides a thorough overview of these innovative approaches, contributing to the ongoing evolution of radiotherapy. The artificial intelligence is also highlighted, emphasizing its role in accelerating progress and achieving goals. It is an essential resource for clinicians, researchers, and students aiming to stay at the forefront of cancer treatment advancements. Adopting new technologies and methodologies greatly enhances cancer patient outcomes worldwide and expands the possibilities in radiotherapy.

2024-01-01T00:00:00Z Özcan, Filiz Hangül, Ceren Özdoğan, Hasan http://hdl.handle.net/20.500.12566/2393 2025-12-12T08:21:31Z 2025-01-01T00:00:00Z

The relationship between diabetes and myricetin: Bibliometric study Özcan, Filiz; Hangül, Ceren; Özdoğan, Hasan Myricetin is an active flavonoid compound known for its beneficial effects in diabetes management. The objective of this study is to characterize the research landscape on myricetin and diabetes by identifying its principal features, emerging trends, and thematic focuses thereby clarifying the therapeutic role of myricetin within the broader diabetes research field. Through bibliometric analysis, this study aims to provide comprehensive data specified to diabetes and myricetin. Material and Methods: R package “Bibliometrix” software was used to perform bibliometric analysis. The analysis included descriptive statistics, scientific mapping, keyword co-occurrence, and network analysis to identify influential elements such as highly cited articles, leading authors and journals, productive countries, and collaborative patterns. Results: The analysis showed limited growth until 2009, followed by rapid expansion. Most documents were original research articles (82.8%), highlighting active data generation. Keyword co-occurrence revealed oxidative stress, flavonoids, polyphenols, antioxidant, and insulin resistance as dominant themes. Twelve clusters were identified, with oxidative stress/myricetin/antioxidant and flavonoids/insulin resistance/phenolic compounds most prominent. Knekt et al. was most globally cited, Ong et al. most locally cited. China, India, Brazil, the United States, and Korea led output, while Journal of Ethnopharmacology, Molecules, and Plants Basel were most productive. Conclusion: The findings reveal a expanding body of research on myricetin in the context of diabetes, with increasing global interest, strong collaborative networks, and a clear thematic emphasis on oxidative stress and flavonoid-related mechanisms. This bibliometric overview provides a structured map of the field and may guide future studies towards unexplored research gaps.; Myricetin, diyabetin yönetiminde faydalı etkileriyle bilinen doğal bir flavonoid bileşiğidir. Bu çalışmanın amacı, myricetin ve diyabet konusundaki araştırma alanını karakterize ederek temel özelliklerini, ortaya çıkan eğilimleri ve tematik odak noktalarını belirlemek, böylece myricetinin terapötik rolünü diyabet araştırmaları bağlamında ortaya koymaktır. Bibliyometrik analiz yoluyla bu alana özgü kapsamlı veriler sunulması hedeflenmiştir. Gereç ve Yöntemler: Bibliyometrik analiz, R tabanlı ''Bibliometrix'' yazılım paketi kullanılarak gerçekleştirilmiştir. Analiz kapsamında betimleyici istatistikler, bilimsel haritalama, anahtar kelime birliktelik analizi ve ağ analizleri yapılmış; en çok atıf alan makaleler, önde gelen yazarlar ve dergiler, üretken ülkeler ve iş birliği örüntüleri belirlenmiştir. Bulgular: Analiz sonuçları, 2009 yılına kadar sınırlı bir yayın artışı olduğunu, bu tarihten sonra ise hızlı bir yükselişin başladığını göstermiştir. Yayınların çoğunluğunu özgün araştırma makaleleri (%82.8) oluşturmakta olup, bu durum alanda aktif veri üretimini yansıtmaktadır. Anahtar kelime analizinde oksidatif stres, flavonoidler, polifenoller, antioksidan ve insülin direnci öne çıkan temalar olmuştur. Toplam 12 tematik küme belirlenmiş; özellikle oksidatif stres/myricetin/antioksidan ve flavonoidler/insülin direnci/fenolik bileşikler kümeleri en belirgin gruplar olarak saptanmıştır. En fazla atıf alan çalışma Knekt ve ark. (2002), en yüksek yerel atıf alan çalışma ise Ong ve ark. (1997) olmuştur. Ülke bazında Çin, Hindistan, Brezilya, ABD ve Kore öne çıkmış; en üretken dergiler Journal of Ethnopharmacology, Molecules ve Plants-Basel olarak belirlenmiştir. Sonuç: Elde edilen bulgular, artan küresel ilgi, güçlü iş birliği ağları ve oksidatif stres ile flavonoid mekanizmalarına odaklı temaların myricetin ve diyabet konusundaki araştırmaların hızla genişleyen bir alan olduğunu göstermektedir. Bu bibliyometrik inceleme, alana ilişkin yapısal bir bakış sunmakta ve gelecekteki araştırmalar için olası boşlukların belirlenmesine katkı sağlamaktadır..

2025-01-01T00:00:00Z Hangül, Ceren Özcan, Filiz Darbaş, Şule Uysal, Hilmi Koç, Ayşe Filiz Berker Karaüzüm, Sibel http://hdl.handle.net/20.500.12566/2377 2025-12-02T10:12:25Z 2025-01-01T00:00:00Z

P1.03 Progesterone may be a regulator and B12 could be an indicator of the proximal D4Z4 repeat methylation status on 4q35ter Hangül, Ceren; Özcan, Filiz; Darbaş, Şule; Uysal, Hilmi; Koç, Ayşe Filiz; Berker Karaüzüm, Sibel FSHD patients have hypomethylation; different course in males and females was linked to sex hormones. We hypothesized that sex hormones, estradiol, testosterone, progesterone, and prolactin might be associated with methylation status of proximal part of D4Z4. We also investigated fT3, folic acid and vitB12 levels. DNA was extracted from 28 FSHD patients and 28 controls for bisulfite methylation analysis, and serum was separated for biochemical analysis of estradiol, testosterone, progesterone, prolactin, fT3, folic acid, and B12. Methylation analysis was specified to DR1, 5P regions, and proximal region covering both DR1 and 5P. Methylation was compared between patients and controls. Then correlation of methylation with estradiol, testosterone, progesterone, prolactin, fT3, folic acid, and B12 was investigated. We found that 5P and proximal region, but not DR1, were significantly hypomethylated in patients compared to controls. Male patients had significant hypomethylation compared to male controls. Older FSHD patients exhibited notable decrease in fT3 levels and hypomethylation of 5P region. Analyses of each CpG revealed seven hypomethylated positions significantly different from controls. Two of the positions demonstrated correlation with progesterone in controls. Except for one position, methylation levels were inversely correlated with B12 in patients. The results indicate that methylation of proximal D4Z4 region, particularly specific positions, may be associated with progesterone. https://www.fshdsociety.org/wp-content/uploads/2025/05/2025-IRC-ABSTRACT-BOOK.pdf

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