Diş Hekimliği Fakültesi / Faculty of Dentistryhttp://hdl.handle.net/20.500.12566/3612024-03-29T07:29:36Z2024-03-29T07:29:36ZEvaluation of the optimal sampling approach for HPV genotyping in circumcised heterosexual men with genital wartsSarıer, MehmetSepin, NevgünEmek, MestanYenidünya Konuk, ElçinKaplan, TuğrulAykan Yüksel, BurcuBarut, ZerrinSakallı Çakçak, DevrimHoşcan, Mustafa Burakhttp://hdl.handle.net/20.500.12566/19892024-03-25T10:56:32Z2023-01-01T00:00:00ZEvaluation of the optimal sampling approach for HPV genotyping in circumcised heterosexual men with genital warts
Sarıer, Mehmet; Sepin, Nevgün; Emek, Mestan; Yenidünya Konuk, Elçin; Kaplan, Tuğrul; Aykan Yüksel, Burcu; Barut, Zerrin; Sakallı Çakçak, Devrim; Hoşcan, Mustafa Burak
Background: Human papillomavirus (HPV) causes a serious socioeconomic burden globally. However, there is currently no consensus on the optimal sampling method for HPVDNA genotyping in circumcised heterosexual men. This study aimed to determine the diagnostic efficacy of 6 different anatomic sampling sites in HPV DNA polymerase chain reaction (PCR) testing of circumcised heterosexual men with genital warts.
Methods: The study included circumcised heterosexual men who presented to our clinic with complaints of genital warts. Swab samples were obtained from the penile shaft (PS), scrotum, coronal sulcus (CS), and external urethral meatus (EUM). First-void urine (FVU) and genital wart biopsy (GWB) were also tested for HPV DNA by PCR.
Results: A total of 32 patients (mean age: 36.9 ± 6.9 years) were included. None of the six samples studied was sufficient on its own to reveal all HPV types detected in a patient. When the samples were analyzed individually, GWB detected an average of 49.5% of total HPV types in a patient. This rate was 50.5% for PS, 40.4% for CS, 31.6% for scrotum, 26.3% for EUM, and 15.8% for FVU samples. The detection rate increased to 75.8% with combined testing of GWB and PS samples, 83.2% with GWB/PS/CS, 90.5% with GWB/PS/CS/scrotum, and 98.9% with GWB/PS/CS/scrotum/EUM samples.
Conclusion: No single anatomic region or sample type can detect all HPV types present in circumcised heterosexual men by PCR assay. The detection rate approaches 99% when wart biopsy is combined with swab sampling of the penile shaft, coronal sulcus, scrotum, and external urethral meatus.
2023-01-01T00:00:00ZThree-dimensional (3D) morphometric analysis of plegic and healthy feet of patients with strokeKaragülle, MehmetYıldırım, YılmazÖzsoy, UmutSüzen, Lütfiye Bikemİkizler May, Haticehttp://hdl.handle.net/20.500.12566/18702024-02-08T08:58:41Z2023-01-01T00:00:00ZThree-dimensional (3D) morphometric analysis of plegic and healthy feet of patients with stroke
Karagülle, Mehmet; Yıldırım, Yılmaz; Özsoy, Umut; Süzen, Lütfiye Bikem; İkizler May, Hatice
Objective: This study aimed to quantitatively assess the changes in foot morphology in stroke patients using 3D scanning and focused on parameters like foot volume, area, and the root mean square difference (RMS) values. The objective was to enhance our understanding of post-stroke foot morphology and its potential relevance for rehabilitation, especially in designing orthotic supports and specialized footwear for stroke patients. Methods: Our study involved fourteen right hemiplegia patients and twenty healthy subjects. Stroke patients were assessed using international scales. We utilized a 3D scanning device to digitize and examine the differences in foot morphology between hemiplegic and healthy subjects, analyzing the data on a computer platform.
Results: In the context of post-stroke individuals with hemiplegic feet, our morphometric analysis revealed notable differences in foot area and foot volume when compared to their healthy counterparts. These distinctions extended to linear measurements encompassing foot length, foot
width, instep height, bimalleolar width, and ball width. Significantly, RMS exhibited a substantial increase in the patient cohort compared to the healthy group (p<0.05). Our investigation also established correlations between these standing morphometric parameters and RMS alterations,
with noteworthy coefficients for various parameters: RMS(Foot Length Difference, 0.41), RMS(Foot Width Difference, 0.45), RMS(Instep Height Difference, 0.58), RMS(Ball Width Difference, 0.58), RMS(Bimalleolar Width Difference, 0.19), RMS(Volume Difference, 0.74), and RMS(Area Difference, 0.62). Conclusion: This study suggests incorporating RMS values as a novel parameter in the evaluation process. We anticipate that these findings will have practical implications, particularly in designing orthotic supports, specialized footwear for stroke patients, and the formulation of tailored rehabilitation programs within clinical settings.
2023-01-01T00:00:00ZThree-dimensional analysis of the difference in asymmetry between the feet of patients with cerebrovascular events and healthy individualsKaragülle, MehmetYıldırım, Yılmazİkizler May, HaticeÖzsoy, UmutSüzen, Lütfiye Bikemhttp://hdl.handle.net/20.500.12566/18692024-02-08T08:35:51Z2023-01-01T00:00:00ZThree-dimensional analysis of the difference in asymmetry between the feet of patients with cerebrovascular events and healthy individuals
Karagülle, Mehmet; Yıldırım, Yılmaz; İkizler May, Hatice; Özsoy, Umut; Süzen, Lütfiye Bikem
Objective: This study aimed to conduct a three-dimensional analysis of foot asymmetry in patients who have suffered cerebrovascular events (stroke) compared to healthy individuals. Methods: A total of fourteen patients experiencing right-sided paralysis and twenty healthy individuals participated in this study. All subjects enrolled in this study were scanned using a three-dimensional scanner to examine their feet. Scanning was conducted with the subject supinely, capturing slightly above the ankle level. The digital image of the left foot was mirrored and superimposed with the right foot to measure asymmetry. Asymmetry was quantified through the root mean square (RMS) difference values, with a higher RMS value indicating increased asymmetry. The study findings illustrate the occurrence of foot asymmetry. Results: The mean RMS values of healthy participants were markedly lower than those of participants with cardiovascular events (p<0.05). Additionally, upon comparing the asymmetry between the right and left feet of healthy participants with identical values in the cardiovascular event group, it was discovered that the right foot of the cardiovascular event group was significantly smaller than the left foot (p<0.05). Conclusion: Patients with cardiovascular events necessitate rehabilitation programs addressing balance and walking difficulties. Furthermore, certain patients with stroke may require orthotic devices. Our study’s results will aid in creating rehabilitation programs and orthotic device designs for stroke patients.
2023-01-01T00:00:00ZInvestigation of the incidence ofaccessory foramen infraorbitale in adult Turkish population in dry skullsCengiz, MenekşeKaragülle, MehmetAlkan, EgeSüzen, Lütfiye Bikemhttp://hdl.handle.net/20.500.12566/18682024-03-21T14:04:10Z2023-01-01T00:00:00ZInvestigation of the incidence ofaccessory foramen infraorbitale in adult Turkish population in dry skulls
Cengiz, Menekşe; Karagülle, Mehmet; Alkan, Ege; Süzen, Lütfiye Bikem
The foramen infraorbitale is the opening in the face of the canalis infraorbitalis, which carries the infraorbital artery, vein and nerve. It is located below the infraorbital margin in the maxilla and is found bilaterally in the facial skeleton. Infraorbital nerve, after leaving the infraorbital foramen, gives its branches by travelling on the anterior surface of the maxilla. During embryological development, the development of an accessory foramen
infraorbitale can be observed especially in the superior medial aspect of the foramen infraorbitale. Knowledge of this variation will increase the effectiveness of anaesthesia during facial applications.The main objective of our study is to investigate the presence of accessory foramen infraorbitale and to contribute to the literature by paying attention to the localisation of accessory foramen infraorbitale. Knowledge of these localisation changes will be useful to increase the effectiveness of local anaesthesia in treatment areas such as maxillofacial surgery,
plastic surgery, dentistry and otolaryngology. In the laboratory of the Department of Anatomy, Akdeniz University Faculty of Medicine, 111 dry skulls were examined and 144 skull halves were measured. The study
was repeated three times with two independent observers. The frequency of accessory foramen infraorbitale in 144 skull halves was 34%; 44.4% of these accessory foramen infraorbitale were found to be on the left and
23.6% on the right. 13.9% were observed bilaterally. The sex of the skulls observed in our study is not known. Future radiological studies in which gender is determined and categorised according to age groups will contribute to the incidence studies in this field. The findings of our study showed that the incidence of accessory foramen infraorbitale is high in the Turkish population. Therefore, it is important to be aware of this variation
during the treatment of patients in anaesthesia applications in the maxillofacial area.
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