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Predicting the impact of cancer somatic mutations on protein-protein interactions
(Antalya Bilim Üniversitesi Lisansüstü Eğitim Enstitüsü, 2022)Cancer is a complex disease with one of the highest mortality rates. An existence challenge in cancer research is to identify the cancer driver mutation that causes cancer progression. Many biological processes are ... -
Utilizing mutual exclusivity for the identification of cancer driver gene modules
(Antalya Bilim Üniversitesi Lisansüstü Eğitim Enstitüsü, 2020)Genomic analyses from large cancer cohorts have revealed the mutational heterogeneity problem which hinders the identification of driver genes based only on mutation profiles. One way to tackle this problem is to incorporate ...